Evaluation Of O-(2-[F-18]-Fluoroethyl)-L-Tyrosine In The Diagnosis Of Glioblastoma

Objective: To assess the feasibility of synthesis of O-(2-[F-18]-fluoroethyl)-L-tyrosine (FET), a new positron emission tomographic (PET) tracer described in several studies but not yet considered standard in management of glioma, in routine practiceandto determine FET uptake in a homogeneous group of patients with suspected high-grade glioma.Design: Prospective nonrandomized trial.Patients: Twelve patients with suspicion of high-grade glioma.Results: The mean (SD) FET uptake ratio was 3.15 (0.72) for the 12 patients and 3.16(0.75) for the 11 patients with glioblastoma.Conclusion: The initial results are promising and indicate that FET PET is a valuable and applicable tool for the imaging of high-grade glioma. Arch Neurol. 2010; 67(3): 370-372