Application Of Maximal Information Coefficient On Identifying Differentially Expressed Micro Rna Associated With Valvular Heart Disease

Valvular heart disease (VHD) is a public-health problem. It may be helpful to get insight into the biological processes and functional disorders of VHD by analyzing miRNA expression profile. A novel statistical method, maximal information coefficient, was introduced into identifying differentially expressed miRNAs related to VHD from case-control expression profiles. This method identified 2 strongly differential expressions of miRNAs in which hsa-miR-221* was a new differentially expressed miRNA by comparing the existing work.