Effects Of Different Dialysis Methods On Calcium And Phosphorus Metabolism, Oxidative Stress And Microinflammation In Patients With Esrd

Objective: To investigate the effects of peritoneal dialysis and hemodialysis on calcium and phosphorus metabolism, oxidative stress, and microinflammation in patients with end-stage renal disease (ESRD). Methods: Patients (n=84) treated with sustained hemodialysis were divided into two groups according to the random number grouping method. Patients (n=42) with peritoneal dialysis (PD) were selected as the observation group and patients (n=42) with hemodialysis (HD) were selected as the control group. Six months after the treatment, serum creatinine, urea nitrogen, urea clearance index (Kt/V), hemoglobin, serum albumin, serum calcium, serum phosphorus, parathyroid hormone (iPTH), inflammatory factors and oxidative stress factors were observed before and after dialysis. Results: After treatment, blood urea nitrogen, serum creatinine and urea clearance index in the control group were lower than those in the observation group while hemoglobin and serum albumin were higher than those in the observation group (all P<0.05). There was no significant difference in serum calcium, phosphorus and parathyroid hormone between the two groups after treatment. After treatment, interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), malondialdehyde (MDA), and advanced oxidation protein products (AOPP) were lower, and superoxide dismutase (SOD) was higher in the observation group than in the control group (all P<0.05). The incidence of complications of infection and hypoproteinemia in the observation group was higher than that in the control group, while the incidence of refractory hypertension, arrhythmia and congestive heart failure in the observation group was lower than that in the control group (P<0.05). Conclusion: There are respective advantages of peritoneal dialysis and hemodialysis. Hemodialysis can effectively remove toxins and improve the nutritional status of patients, while peritoneal dialysis can improve microinflammation and oxidative stress. These two methods can be used according to the condition of patients.