Class A Gpcr: Serotonin Receptors

Hundreds of studies have reported that G protein-coupled receptors self-associate to form dimers or oligomers. Yet, this topic remains controversial. This chapter reviews the current literature related to the structure and function of 5-HT receptor dimers/oligomers in recombinant cells and in native tissues. Studies designed to examine the functional significance of 5-HT receptor dimer/oligomer formation are evaluated and discussed. Emphasis is placed on the methods employed, the dimer interface, oligomer size, mechanism of G protein activation, and analysis of bivalent ligands as potential therapeutics.