Polymorphisms Of Vegf And Congenital Heart Disease In A Chinese Population
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE(2016)
摘要
Spatiotemporal expression pattern of vascular endothelial growth factor (VEGF) are required for proper heart morphogenesis. Genetic variants of VEGF contribute to the production and/or biological activity may determine the risk of congenital heart disease (CHD). To explore the impact of VEGF functional SNPs -2578 C>A, -1498 T>C, -634 G>C, + 936 C>T on the susceptibility of CHD, we genotyped four functional polymorphisms of VEGF (-2578 C>A, -1498 T>C, -634 G>C, + 936 C>T) in a hospital based case-control study of 476 CHD cases and 557 non-CHD controls in a Chinese population. We did not find any significant associations between the four VEGF polymorphisms and the risk of CHD or a certain kind of CHD such as ventricular septal defect (VSD) or tetralogy of Fallot (TOF). However, C-2578 T-1498 G(-634) C+936, C-2578 T-1498 C-634 T+936 and G(-2578) G(-1498) G(-634) T+936 haplotypes were correlated with a significantly increased susceptibility of CHD. The C-2578 T-1498 G(-634) T+936 haplotypes were correlated with a significantly decreased risk of CHD.
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关键词
VEGF, polymorphisms, congenital heart disease, single nucleotide polymorphisms, molecular epidemiology
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