Association Of Pro-Inflammatory Cytokines Gene Polymorphisms With Parkinson'S Disease In Chinese Population

The progressive neurodegenerative process in Parkinson's disease (PD) is accompanied by chronic inflammation, including activation of microglia and astrocytes that express pro-inflammatory cytokines. Up to now, abundant evidence from genetic epidemiology have been assessed the association of pro-inflammation cytokines gene polymorphisms and risk of PD in different ethnicity, but conflicting results were obtained due to the heterogeneity of the genetic background among populations. Here, we recruited 248 PD patients, and 226 matched healthy controls from Jiangsu Province to estimate the influence of IL-6 rs1800795, IL-10 rs1800896 and TNF-alpha rs1800629 polymorphism on patients with Parkinson's disease. Single nucleotide polymorphism locus was genotyped using PCRRFLP. The genotypic and allelic frequency of TNF- alpha, IL-6 did not show significant difference between PD and normal controls. However, the frequency of wild (AA) and homozygous mutant (CC) genotype IL-10 rs1800896 genotypes in cases and controls was found more in controls (43% and 5.7% respectively), but that of the heterozygous genotype was higher (60.15%) in cases with PD patients. In conclusion, no relationship between IL-6, and TNF- a genotypes or alleles and PD susceptibility was revealed. However, IL-10 rs1800896 GA genotype confers genetically susceptibility to PD in Chinese population.