Application Of Multi-Slice Spiral Ct In Measuring Airway Remodeling Of Asthma In Children

To investigate and discuss the application value of multi-slice spiral CT in measuring airway remodeling of asthma in children. A total of 70 children with moderate and severe asthma admitted and treated in our hospital from June 2016 to May 2017 were enrolled into observation group, and 70 healthy children in the same period were collected for control group. Multi-slice spiral CT was performed for children from both groups to observe the lung imaging characteristics. The wall thickness (WT), inner diameter of lumen (Din), wall area (WA) and wall area percentage (WA%) of the bronchi in the apical segment of upper left lung, apical segment of upper right lung, posterior segment of lower left lung and posterior segment of lower right lung were measured and compared respectively by Thoracic VCAR, a chest volume acquisition and reconstruction software. All children were treated with salbutamol and budesonide for three months and then measured with CT for retrospective study. The CT examination results showed that no special signs were detected in the lungs of children in control group while thick bronchial wall and bronchial stenosis were found in the lungs of children from observation group. The bronchus WT in each segment in observation group was significantly enlarged compared with that in control group (P<0.05). The bronchus Din from observation group was significantly smaller than that in control group, which indicated that the bronchus lumens of children with moderate and severe asthma are narrow (P<0.05). The bronchus WA in observation group was significantly enlarged compared with that in control group (P<0.05). As compared with those before treatment, the average values of WT, WA and WA% of children with asthma after treatment were all significantly decreased but the average value of Din was significantly increased (P<0.05). Our data demonstrates that multi-slice spiral CT can be used to measure the airway remodeling of children with asthma and evaluate the severity of asthma, which is valuable in predicting prognosis and provide beneficial guidance for the clinical treatment of asthma in children.