Cooperative Protein Allosteric Transition Mediated by a Fluctuating Transmission Network

•We investigate the time-dependent progression of allostery in a bistable protein.•The microscopic mechanism can be revealed by a correlation analysis.•Allosteric communication is mediated via a network of intra-protein contacts.•Allosteric transitions are cooperative, i.e., all contacts need to change in unison.•The cooperative process is fluctuation-driven as in an Ising-type model.