Transcriptional regulation of neonatal neural stem cells is a determinant of social behavior
biorxiv(2021)
摘要
Rare gene variants confer a high level of penetrance to neurodevelopmental disorders, but their developmental origin and cellular substrates remain poorly understood. To address this limitation, we explored the role of TBX1 , a gene encoded in a rare copy number variant, in cell and mouse models. Here, we report that neonatal Tbx1 deficiency contributes to defective peripubertal social behavior and impairs the proliferation of neonatal neural stem/progenitor cells. Moreover, TBX1 transcriptionally regulates genes linked to post-embryonic neurogenesis and neurodevelopmental disorders associated with other rare gene variants. Our data indicate a precise time window and cell type through which the social dimension is altered by a gene encoded in a rare CNV and provide a potential common mechanistic basis for a group of neurodevelopmental disorders.
One-Sentence Summary Tbx1 , a gene affecting neonatal stem cell proliferation, influences peripubertal social behavior.
### Competing Interest Statement
The authors have declared no competing interest.
更多查看译文
关键词
neonatal neural stem cells,stem cells,transcriptional regulation,social
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要