Macrocyclization As a Source of Desired Polypharmacology. Discovery of Triple PI3K/mTOR/PIM Inhibitors.
Sonia Martinez-Gonzalez,Rosa M. Alvarez,Jose Martin,Ana Belen Garcia,Concepcion Riesco-Fagundo,Carmen Varela,Antonio Rodriguez Hergueta,Esther Gonzalez Cantalapiedra,M. Albarran,Elena Gomez-Casero,Antonio Cebria,Enara Aguirre,Nuria Ajenjo,David Cebrian,Bruno Di Geronimo,Darren Cunningham,Michael O'Neill, Harish P. G. Dave,Carmen Blanco-Aparicio,Joaquin Pastor ACS medicinal chemistry letters（2021）
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Polypharmacology,PI3K(+/- mTOR)/PIM inhibitors,anticancer therapies,macrocycles
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