Brain connectivity-based prediction of real-life creativity is mediated by semantic memory structure

Creative cognition relies on the ability to form remote associations between concepts, which allows to generate novel ideas or solve new problems. Such an ability is related to the organization of semantic memory; yet whether real-life creative behavior relies on semantic memory organization and its neural substrates remains unclear. Therefore, this study explored associations between brain functional connectivity patterns, network properties of individual semantic memory, and real-life creativity. We acquired multi-echo functional MRI data while participants underwent a semantic relatedness judgment task. These ratings were used to estimate their individual semantic memory networks, whose properties significantly predicted their real-life creativity. Using a connectome-based predictive modeling approach, we identified patterns of task-based functional connectivity that predicted creativity-related semantic memory network properties. Furthermore, these properties mediated the relationship between functional connectivity and real-life creativity. These results provide new insights into how brain connectivity supports the associative mechanisms of creativity. ### Competing Interest Statement The authors have declared no competing interest.