Sylites: Multipurpose markers for the visualization of inhibitory synapses
biorxiv(2021)
摘要
We introduce Sylites – small and versatile fluorogenic affinity probes for high-contrast visualization of inhibitory synapses. Having stoichiometric labeling and exceptional selectivity for neuronal gephyrin, a hallmark protein of the inhibitory post-synapse, Sylites enable superior synapse staining compared with antibodies. Combined with super-resolution microscopy, Sylites allow precise nanoscopic measurements of the synapse. In brain tissue, Sylites reveal the three-dimensional distribution of inhibitory synapses within just an hour.
### Competing Interest Statement
H.M.M. and V.K. filed a utility model concerning Sylites.
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关键词
inhibitory synapses,multipurpose markers,visualization
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