VPRBP Functions Downstream of the Androgen Receptor and OGT to Restrict p53 Activation in Prostate Cancer.

Ninu Poulose,Nicholas Forsythe,Adam Polonski,Gemma Gregg,Sarah Maguire,Marc Fuchs,Sarah Minner,Guido Sauter,Simon S McDade,Ian G Mills

Molecular cancer research : MCR（2022）

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摘要

In conclusion, we have shown that VPRBP/DCAF1 promotes prostate cancer cell proliferation by restraining p53 activation under the influence of the AR and OGT.

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关键词

androgen receptor,vprbp functions downstream,prostate cancer,p53 activation

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