Increased excitability of human iPSC-derived neurons in HTR2A variant-related sleep bruxism

Avijite Kumer Sarkar,Shiro Nakamura,Kento Nakai,Taro Sato,Takahiro Shiga,Yuka Abe,Yurie Hoashi,Tomio Inoue,Wado Akamatsu,Kazuyoshi Baba

biorxiv（2022）

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摘要

•Electrophysiological properties of human iPSC-derived neurons mature over time.•A strategy to define the functional maturity of human neurons in vitro.•Sleep bruxism (SB) neurons exhibited higher action potential firing frequency.•SB neurons displayed shorter action potential half duration.•The first human iPSC-derived neuronal model to study sleep bruxism.

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关键词

SB,SNP,iPSC,HTR2A,5-HT2AR,DMEM,FGF-2,DIV,Shh,PM,BDNF,GDNF,TGF-β,GAPDH,RA,RMP,Rm,τm,Cm,AP,SEM

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