A phase 2 randomized controlled dose-ranging trial of recombinant pertussis booster vaccines containing genetically inactivated pertussis toxin in women of childbearing age

Kulkanya Chokephaibulkit,Thanyawee Puthanakit, Niranjan Bhat,Souad Mansouri, Yuxiao Tang,Keswadee Lapphra, Supattra Rungmaitree,Suvaporn Anugulruengkitt,Watsamon Jantarabenjakul, Indah Andi-Lolo,Renee Holt, Librada Fortuna,Chawanee Kerdsomboon, Pailinrut Chinwangso, Ladda Suwitruengrit, Anita H.J. van den Biggelaar,Simonetta Viviani, Pham Hong Thai,Bruce L. Innis

Vaccine（2022）

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摘要

•Recombinant inactivated pertussis vaccines are safe in non-pregnant women.•Lower-dose genetically-inactivated pertussis toxin has comparable immunogenicity.•Monovalent recombinant pertussis vaccine shows favorable immunogenicity and safety.

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关键词

Pertussis,Genetically-inactivated,Low-dose,Non-pregnant,Safety,Immunogenicity

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