Decision value signals in the ventromedial prefrontal cortex and motivational and hedonic symptoms across mood and psychotic disorders

Min K Souther,Daniel H Wolf,Rebecca Kazinka,Sangil Lee,Kosha Ruparel,Mark A Elliott,Anna Xu,Matthew Cieslak,Greer Prettyman,Theodore D Satterthwaite,Joseph W Kable

NeuroImage: Clinical（2022）

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摘要

•Anhedonia and amotivation are common symptoms across mood and psychotic disorders.•Value signals in the brain were measured using a delay discounting task during fMRI.•Anhedonia and amotivation were linked to dampened value-related signals.•This brain-symptom relationship was specific to anhedonia and amotivation.

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关键词

Anhedonia,Depression,Bipolar disorder,Schizophrenia,Ventromedial prefrontal cortex,fMRI

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