Interaction with 2,4-dinitrophenol correlates with polyreactivity, self-binding, and stability of clinical-stage therapeutic antibodies

•Human immunoglobulin repertoires contain antibodies that bind to dinitrophenol.•Among 112 clinical-stage therapeutic IgG1 antibodies about 20 % bind dinitrophenol considerably.•Interaction of antibodies with dinitrophenol correlated with important developability parameters.