Glucocorticoid receptor mediates corticosterone-thyroid hormone synergy essential for metamorphosis in Xenopus tropicalis tadpoles

General and Comparative Endocrinology（2022）

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摘要

•Signaling through GR in tadpoles was blocked using knockout frogs and RU486.•GRKO tadpoles can survive metamorphosis with exogenous thyroid hormone.•Corticosterone has no effect on TH-dependent events without GR signaling.

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ACTH,ACTHKO,cDNA,CORT,GR,GRKO,klf9,MR,NF,PCR,qPCR,rpl8,RU486,T3,TH,thrb,WT

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