Impact of Activation Threshold Selection and Data Averaging to Improve Pressure Estimation using Ultrasound Imaging and Phase-Change Contrast Agents

A phase-change contrast agent (PCCA) is a liquid nanodroplet (ND) that can phase transition into a gaseous microbubble (MB) when exposed to pulsed ultrasound (US) of sufficient peak negative pressure. Previously, our group has shown that PCCA activation is linearly related to the hydrostatic pressure of the surrounding media. As increases in the hydrostatic pressure requires higher US energies to ...