Molecular Characterization of Peritoneal Involvement in Primary Colon and Ovary Neoplasm: The Possible Clinical Meaning of the P2X7 Receptor-Inflammasome Complex.

Anna Solini,Luigi Cobuccio,Chiara Rossi,Federico Parolini,Edoardo Biancalana,Stefania Cosio,Massimo Chiarugi,Angiolo Gadducci

European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes（2022）

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摘要

We show here that rarely measured molecules seem to specifically characterize omental carcinomatosis of CC or EOC, while more common inflammatory agents like TNFα, TGFβ, or MCP-1 do not; the P2X7R-NLRP3 complex marks omental and peritoneal carcinosis and is related to circulating white blood cells and MCP-1, involved in monocyte-macrophage tissue infiltration; increased TGFβ and FGFR1 characterize the tumoral dissemination.

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关键词

Colon cancer,NLRP3 inflammasome,Ovarian cancer,P2X7 receptor,Peritoneal carcinomatosis

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