Euphorfinoids A and B, a pair of ent -atisane diterpenoid epimers from the roots of Euphorbia fischeriana, and their bioactivities.

Euphorfinoids A and B ( and ), a pair of -atisane diterpenoid epimers with a vicinal 2,3-diol moiety, together with four known analogues (), were isolated from the roots of wild . Their structures were elucidated by spectroscopic analysis, including extensive NMR, HR-ESIMS, NMR calculations, X-ray diffraction, and comparison with structurally related known analogues. Our bioassays have established that compound displayed moderate anti-proliferative effects on Hcc1806 cell line with IC 15.53 ± 0.21 μM, and compound showed remarkable inhibitory effects against AChE with IC 32.56 ± 2.74 μM by an screened experiment.