IL-6 and IL-8 are likely associated with psychological status in treatment naïve general population

•We comprehensively investigated the association between inflammatory biomarker and psychological disorders in treatment-naive individuals in a large community-based cohort.•Depressive status may positively associated with serum interleukin-6 in treatment-naive individuals•Stress status may negatively associated with serum interleukin-8 in treatment-naive individuals.