Perinatal exposure to the thyroperoxidase inhibitors methimazole and amitrole perturbs thyroid hormone system signaling and alters motor activity in rat offspring

•TPO inhibitors MMI and amitrole elicit similar disruptions of the thyroid hormone system.•MMI and amitrole perturb thyroid hormone dependent rat brain development via TPO inhibition.•MMI and amitrole reduce expression of thyroid hormone-sensitive genes in cerebral cortex.•MMI and amitrole alter motor activity of perinatally exposed rat offspring.