Combination of zinc and selenium alleviates ochratoxin A-induced fibrosis via blocking ROS-dependent autophagy in HK-2 cells

Guannan Le,Lulu Yang,Heng Du,Lili Hou,Lei Ge,Ardache Sylia,Azhar Muhmood, Xinxiang Chen,Bo Han,Kehe Huang

Journal of Trace Elements in Medicine and Biology（2022）

引用 9|浏览10

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摘要

•OTA induced cytotoxicity and increased fibrosis factors expression in HK-2 cells.•Zinc and SeMet alone or in combination alleviated OTA-induced cytotoxicity and fibrosis in HK-2 cells.•Protective effects of zinc and SeMet combined application were better than its alone.•Zinc and SeMet alleviated OTA-induced fibrosis via blocking ROS-dependent autophagy signaling pathway.

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关键词

α-SMA,AKT,ANOVA,BEN,CKD,DAPI,ECM,HK-2cells,H2O2,LC3 II,LDH,MTT,mTOR,OTA,PVDF,ROS,SD,SeMet,TGF-β,TBS

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