The specific role of the striatum in interval timing: The Huntington’s disease model

Laurie Lemoine,Marine Lunven,Blanche Bapst,Laurent Cleret de Langavant,Vincent de Gardelle,Anne-Catherine Bachoud-Lévi

NeuroImage: Clinical（2021）

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摘要

•Patients with Huntington’s Disease (HD) report a temporal deficit in daily life.•We tested HD gene carriers and controls in spatial (cm) and temporal (s) tasks.•Early stage HD patients, but not presymptomatic carriers, were more impaired in time.•Striatal volume was associated with the temporal deficit in gene carriers.•Evaluation of interval timing processing should be used as a clinical tool.

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关键词

Interval timing,Time processing,Striatum,Huntington’s disease,Disorientation

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