Macrophages regulates the transition of pericyte to peritoneal fibrosis through the GSDMD/IL-1β axis

Qiuyuan Shao,Cheng Sun,Qingyan Zhang,Jin Liu,Yangyang Xia,Bo Jin,Xiaoping Qian

International Immunopharmacology（2021）

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摘要

•GSDMD was up-regulated in macrophages in dextrose peritoneal dialysate-induced mice.•GSDMD knockdown inhibited IL-1β production in macrophages.•GSDMD knockdown in mononuclear macrophages suppressed fibrosis in pericytes.•GSDMD knockdown in mononuclear macrophages down-regulated VEGF/PI3K pathway in pericytes.•GSDMD knockout inhibits peritoneal fibrosis in pericytes in vivo.

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关键词

Macrophages,Peritoneal fibrosis,Pericytes,End stage renal disease,GSDMD/IL-1β

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