Expression of GALNT8 and O-glycosylation of BMP receptor 1A suppress breast cancer cell proliferation by upregulating ERα levels

Tianmiao Huang,Qiong Wu,Huang Huang,Cheng Zhang,Liping Wang,Lingyan Wang,Yangzhi Liu,Wenli Li,Jianing Zhang,Yubo Liu

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS（2022）

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摘要

•GALNT8 elevated the transcription and protein levels of ERα and suppressed breast cancer cells proliferation.•O-GalNAcylation of BMP receptor 1A was modulated by GALNT8.•GALNT8 enhances expression of ERα by activating BMP/SMAD/RUNX2 signaling pathway.

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关键词

GALNT8, O-GalNAcylation, ER alpha, BMP type I receptor, Breast cancer

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