Risk factors associated with thyroid nodular disease in acromegalic patients: A case-cohort study in a tertiary center

Guadalupe Vargas-Ortega,Carlos Alfonso Romero-Gameros,Mario Enrique Rendón-Macias,Lourdes Balcázar-Hernández,Ernesto Sosa-Eroza,Moises Mercado, Ana L Espinosa de Los Monteros-Sánchez, Barbara Pérez-Aguilar,Carlos Paredes-Manjarrez, Fernando Bernardo Reyes-Olhagaray, Diana Laura Serrano-Ramírez, Erick Vladimir Martínez-De la Cruz,Baldomero González-Virla

Growth Hormone & IGF Research（2021）

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摘要

•IGF-1 x ULN ≥ 2.2 is associated with an increased probability of TND in patients with acromegaly•The risk attributable to an excess of the GH/IGF-1 axis activity could depends on the time of exposure, leading to an increased likelihood of TND.•The probability of developing thyroid nodular disease in patients with acromegaly is higher than in the general population

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关键词

Acromegaly,IGF-1,Thyroid nodules,Risk factors

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