GATA-3 and T-bet as diagnostic markers of non-esophageal eosinophilic gastrointestinal disease

Eosinophilic gastrointestinal diseases (EGID) represent a spectrum of disorders classically defined by eosinophil-predominant inflammation. Currently, there are no consensus diagnostic criteria for non-esophageal EGIDs. In contrast to the esophagus, eosinophils are resident cells in the gastrointestinal mucosa; therefore, establishing histologic thresholds indicative of pathology is more challenging. EGID are associated with Th2 inflammation. The master transcriptional regulators of Th1 and Th2 inflammation are T-bet and GATA-3, respectively.