Correction to: Vaccination for Patients with Inborn Errors of Immunity: A Nationwide Survey in Japan
JOURNAL OF CLINICAL IMMUNOLOGY(2022)
摘要
Abstract We conducted a nationwide survey of inborn errors of immunity (IEI) in Japan for the second time in 10 years, focusing on protective measures for IEI patients against infectious diseases. Questionnaires were sent to various medical departments nationwide, and a total of 1,307 patients were reported. The prevalence of IEI was 2.2 patients per 100,000 population which was comparable with the previous nationwide study. The most common disease category was autoinflammatory disorders (25%), followed by antibody deficiencies (24%) and congenital defects of phagocyte number or function (16%). We found that a significant number of patients received contraindicated vaccines, principally because the patients were not diagnosed as IEI by the time of the vaccination. Regarding diseases for which BCG vaccination is contraindicated, 43% patients had actually received BCG, of which 14% developed BCG related infections. In order to prevent IEI patients from receiving inadequate vaccines, the continuous education to parents and physicians is needed, along with the expansion of newborn screening, but efforts to screen IEI at the site of vaccination also remains important.
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关键词
vaccination,immunity,inborn errors
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