Late Skeletal Effects in Sheep Treated as Lambs With Targeted vs. Wide Symmetrical Spinal Fields.

We found no differences in spinal curvature or length in fully-grown sheep between targeted and wide spinal RT characteristic of CSI that had been irradiated as young lambs. This suggests that targeted photon fields may be applied to children receiving CSI, potentially reducing their risks of long-term toxicities, including secondary malignancies. Studies on human subjects are needed to confirm the same findings with children receiving CSI.