Derivation of Distinct Prognostic Tumor Cell States in PDAC via Single-Cell RNA Sequencing

P. Chati,E.P. Storrs,A. Usmani,B. Krasnick,T. Hollander,F. Qaium, A. Hephzibah,I. Sloan,S. Badiyan, G.D. Lang, N.D. Cosgrove,V.M. Kushnir,D.K. Mullady,D.S. Early,W. Hawkins,L. Ding,R.C. Fields,K.K. Das,A.A. Chaudhuri

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS（2021）

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摘要

We analyzed scRNA-seq data from 58 independent PDAC patients, which we used to identify 5 distinct tumor cell states. These tumor cell states appear to correspond with the previously reported "squamous-like" or "basal" vs. "classical" subtypes, correlate significantly with overall survival, and could potentially inform more personalized treatment strategies including radiotherapy in the future.

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关键词

pdac,rna,tumor,single-cell

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