Observation of Substrate Diffusion and Ligand Binding in Enzyme Crystals Using High-Repetition-rate Mix-and-inject Serial Crystallography
IUCRJ（2021）
关键词
substrate diffusion in crystals,antibiotic resistance,beta-lactamases,enzyme kinetics,irreversible inhibition,mix-and-inject serial crystallography,serial femtosecond crystallography,European X-ray Free-Electron Laser,megahertz pulse-repetition rate,protein structure determination,drug discovery,ceftriaxone,sulbactam,X-ray crystallography,enzyme mechanisms
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