New risk factors for early- and late-onset cardiac rupture in ST-elevation myocardial infarction patients after primary percutaneous coronary intervention

•This case-control study documents new risk factors strongly related with cardiac rupture (CR) after primary percutaneous coronary intervention.•Acute hyperglycemia and thrombocytopenia are strongly associated with early and late CR, respectively.•Emergent surgical repair may lead to a reduction of in-hospital mortality in CR patients.•Early prediction of CR using clinical risk factors may improve mortality in ST-elevation myocardial infarction patients.