Diagnostic value of cardiac natriuretic peptide on pulmonary hypertension in systemic sclerosis: A systematic review and meta-analysis

•Cardiac natriuretic peptides are often elevated in systemic sclerosis secondary pulmonary arterial hypertension (SSc-PAH) patients and are considered as useful markers for PAH.•We summarized diagnostic evidence of B-type natriuretic peptide (BNP)/N-terminal pro-BNP (NT-proBNP) for SSc-PAH and evaluate their clinical application value.•The meta-analysis included 9 studies involving 479 patients.•NT-proBNP has certain diagnostic value for PAH due to its better specificity and moderate sensitivity.