Familial clustering of primary lateral sclerosis and amyotrophic lateral sclerosis: Supplementary evidence for a continuum

In their article, Corcia et al. describe a series of 9 patients suffering from primary lateral sclerosis (PLS) coming from different family clusters, in which every individual had a first- or second-degree relative affected by amyotrophic lateral sclerosis (ALS). The authors concluded from their results, that adult-onset PLS might be an inherited disease, and that there was a continuum between PLS and ALS, as both diseases coexisted in the reported kinships [1].