Spinal γ-Aminobutyric Acid Interneuron Plasticity Is Involved in the Reduced Analgesic Effects of Morphine on Neuropathic Pain

Tadanao Hiroki,Takashi Suto,Jo Ohta,Shigeru Saito,Hideaki Obata

The Journal of Pain（2022）

引用 3|浏览6

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摘要

•Periaqueductal gray (PAG) morphine has no analgesic effects against neuropathic pain.•PAG morphine increases spinal 5-hydroxytryptamine (5-HT), and a 5-HT3 agonist increases spinal γ-aminobutyric acid (GABA).•Morphine activates GABAergic interneurons in the spinal dorsal horn.•The function of inhibitory GABA receptors is altered after nerve injury.•GABA receptors contribute to the reduced efficacy of morphine for neuropathic pain.

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Morphine,neuropathic pain,serotonin,descending pain modulation,γ-aminobutyric acid

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