Tracing the Origin, Spread, and Molecular Evolution of Zika Virus in Puerto Rico, 2016-2017

Gilberto A Santiago,Chaney C Kalinich,Fabiola Cruz-López,Glenda L González,Betzabel Flores,Aaron Hentoff,Keyla N Charriez,Joseph R Fauver,Laura E Adams,Tyler M Sharp,Allison Black,Trevor Bedford,Esther Ellis,Brett Ellis,Steve H Waterman,Gabriela Paz-Bailey,Nathan D Grubaugh,Jorge L Muñoz-Jordán

EMERGING INFECTIOUS DISEASES（2021）

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摘要

We reconstructed the 2016-2017 Zika virus epidemic in Puerto Rico by using complete genomes to uncover the epidemic's origin, spread, and evolutionary dynamics. Our study revealed that the epidemic was propelled by multiple introductions that spread across the island, intricate evolutionary patterns, and approximate to 10 months of cryptic transmission.

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关键词

NGS,Puerto Rico,United States,Zika,Zika virus,genomic epidemiology,molecular evolution,next-generation sequencing,phylogenetics,vector-borne infections,viruses

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