Evaluation of Hepatic Iron Overload Using a Contemporary 0.55 T MRI System

Background MRI T2* and R2* mapping have gained clinical acceptance for noninvasive assessment of iron overload. Lower field MRI may offer increased measurement dynamic range in patients with high iron concentration and may potentially increase MRI accessibility, but it is compromised by lower signal-to-noise ratio that reduces measurement precision. Purpose To characterize a high-performance 0.55 T MRI system for evaluating patients with liver iron overload. Study Type Prospective. Population Forty patients with known or suspected iron overload (sickle cell anemia [n = 5], ss-thalassemia [n = 3], and hereditary spherocytosis [n = 2]) and a liver iron phantom. Field strength/sequence A breath-held multiecho gradient echo sequence at 0.55 T and 1.5 T. Assessment Patients were imaged with T2*/R2* mapping 0.55 T and 1.5 T within 24 hours, and 16 patients returned for follow-up exams within 6-16 months, resulting in 56 paired studies. Liver T2* and R2* measurements and standard deviations were compared between 0.55 T and 1.5 T and used to validate a predictive model between field strengths. The model was then used to classify iron overload at 0.55 T. Statistical Tests Linear regression and Bland-Altman analysis were used for comparisons, and measurement precision was assessed using the coefficient of variation. A P-value < 0.05 was considered statistically significant. Results R2* was significantly lower at 0.55 T in our cohort (488 +/- 449 s(-1) at 1.5 T vs. 178 +/- 155 s(-1) at 0.55 T, n = 56 studies) and in the patients with severe iron overload (937 +/- 369 s(-1) at 1.5 T vs. 339 +/- 127 s(-1) at 0.55 T, n = 23 studies). The coefficient of variation indicated reduced precision at 0.55 T (3.5 +/- 2.2% at 1.5 T vs 6.9 +/- 3.9% at 0.55 T). The predictive model accurately predicted 1.5 T R2* from 0.55 T R2* (Bland Altman bias = -6.6 +/- 20.5%). Using this model, iron overload at 0.55 T was classified as: severe R2* > 185 s(-1), moderate 81 s(-1) < R2* < 185 s(-1), and mild 45 s(-1) < R2* < 91 s(-1). Data Conclusion We demonstrated that 0.55 T provides T2* and R2* maps that can be used for the assessment of liver iron overload in patients. Evidence Level 2 Technical Efficacy Stage 2