Combination of parathyroid hormone pretreatment and mechanical stretch promotes osteogenesis of periodontal ligament fibroblasts

Fan Li, Mengya He,Shengnan Li,Yuxing Bai

American Journal of Orthodontics and Dentofacial Orthopedics（2022）

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摘要

•Uniaxial cyclic stretch was exerted on periodontal ligament fibroblasts.•Parathyroid hormone (PTH) potentiated the mechanically induced osteogenesis in a synergistic pattern.•PTH1R played a crucial role in the synergistic effect of PTH and mechanical stretch.•The Wnt/β-catenin pathway mediates the interaction of PTH and mechanical stretch.

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