Brain amyloid burden, sleep, and 24-hour rest/activity rhythms: screening findings from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration Studies.

Adam P Spira,Vadim Zipunnikov,Rema Raman,Jiyoon Choi,Junrui Di,Jiawei Bai,Cynthia M Carlsson,Jacobo E Mintzer,Gad A Marshall,Anton P Porsteinsson,Roy Yaari,Sarah K Wanigatunga,John Kim,Mark N Wu,Paul S Aisen,Reisa A Sperling,Paul B Rosenberg

Sleep advances : a journal of the Sleep Research Society（2021）

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摘要

Although we found no association of preclinical AD with standard actigraphic sleep or RAR metrics, a novel data-driven analytic method identified temporally "local" RAR alterations in preclinical AD.

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关键词

Alzheimer’s disease,actigraphy,activity,amyloid,circadian,cognitive,rhythm,sleep,wrist

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