Cell-Associated Human Immunodeficiency Virus (HIV) Ribonucleic Acid Has a Circadian Cycle in Males With HIV on Antiretroviral Therapy.

Jared Stern,Ajantha Solomon,Ashanti Dantanarayana,Rachel Pascoe,Arnold Reynaldi,Miles P Davenport,Jeffrey Milush,Steven G Deeks,Wendy Hartogensis,Frederick M Hecht,Leslie Cockerham,Michael Roche,Sharon R Lewin

The Journal of infectious diseases（2022）

引用 6|浏览17

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摘要

Cell-associated unspliced HIV RNA in PWH on ART varies temporally with a circadian rhythm. These findings have implications for the design of clinical trials and biomarkers to assess HIV cure interventions.

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关键词

HIV RNA,HIV latency,HIV transcription,circadian rhythm,estradiol

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