Correction to: Sperm miR-34c-5p Transcript Content and Its Association with Sperm Parameters in Unexplained Infertile Men
Reproductive Sciences(2021)
摘要
MicroRNAs (miRNAs) play an essential role in regulatory functions during gametogenesis. There is evidence that dysregulation of miR-34c-5p is implicated in the pathogenesis of male infertility. Whether miR-34c-5p expression could represent the semen quality and be useful in prediction of the fertilizing ability in normozoospermic men was examined in this study. Normozoospermic infertile patients ( n = 15) and fertile men ( n = 15) were recruited from the Infertility Clinic of Ahvaz, Iran. Sperm contents of miR-34c-5p transcript in were assessed using real-time polymerase chain reaction. No significant differences were seen in semen characteristics between patients and fertile men. Infertile patients showed significant ( p = 0.019) lower contents of sperm miR-34c-5p than fertile controls. Men with lower transcript contents of miR-34c-5p exhibit lower sperm motility and normal morphology. Sperm miR-34c-5p transcript with a relatively good diagnostic power discriminated unexplained infertile men (AUC = 0.751, 95% CI: 0.568–0.934; p = 0.019). Our findings show that sperm contents of miR-34c-5p transcript could reflect the quality of spermatozoa in etiology of unexplained male infertility and be helpful in predicting a successful pregnancy.
更多查看译文
关键词
miRNAs, miR-34c-5p, Spermatozoa, Unexplained infertility
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要