TP53 Co-Mutational Features and NGS-Calibrated Immunohistochemistry Threshold in Gastric Cancer.

Ruili Yu,Tingyi Sun,Xianwei Zhang,Zhen Li,Yang Xu,Kaihua Liu,Yuqian Shi,Xue Wu,Yang Shao,Lingfei Kong

OncoTargets and therapy（2021）

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摘要

Our results indicated that exclusivity between and mutations could be potentially used as a cost-effective way to predict status. Also, setting proper IHC thresholds for each specific antibody is critical to accurately detect mutations and facilitate disease diagnosis.

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关键词

TP53,co-mutation,gastric cancer,immunohistochemistry threshold,next-generation sequencing

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