Gonadal tumor and malignancy in 118 patients with disorders of sex development with Y chromosome

Objective To provide more information about tumor prevalence and malignant transformation among patients with disorders of sex development (DSD) for further guidance in prophylactic gonadectomies and surveillance. Methods SPSS software (version 20.0) was used for all statistical analyses. Results Phenotypically female DSD patients with a Y chromosome have a higher risk of gonadal malignancy. Conclusion Bilateral gonadal resection is recommended as soon as diagnosis is made for phenotypically female patients with disorders of sex development with a Y chromosome.