WEE1i-ATRi combination therapy: a promising low-dose treatment for CCNE1 -amplified gynecologic cancers.
Cell reports. Medicine（2021）
摘要
amplification is an oncogenic driver for many gynecologic cancers and is associated with poor patient outcomes. In this issue, Xu et al. identify a combination therapy that is responsive to high -copy number ovarian and endometrial cancers using PDX models.
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