A Novel Methodology For The Efficient Synthesis Of 3-Monohalooxindoles By Acidolysis Of 3-Phosphate-Substituted Oxindoles With Haloid Acids

A novel method for the synthesis of 3-monohalooxindoles by acidolysis of isatin-derived 3-phosphate-substituted oxindoles with haloid acids was developed. This synthetic strategy involved the preparation of 3-phosphate-substituted oxindole intermediates and S(N)1 reactions with haloid acids. This new procedure features mild reaction conditions, simple operation, good yield, readily available and inexpensive starting materials, and gram-scalability.