Chemokine receptor antagonists enhance morphine's antinociceptive effect but not respiratory depression

Saadet Inan,Xiaohong Chen, Eric M. Eisenstein,Joseph J. Meissler,Ellen B. Geller,Christopher Tallarida,Mia Watson, Menahem Doura,James E. Barrett,Alan Cowan,Scott M. Rawls,Martin W. Adler,Toby K. Eisenstein

Life Sciences（2021）

引用 4|浏览20

暂无评分

摘要

•Chemokine receptor antagonists (CRAs) enhanced morphine's antinociceptive effect.•The CRAs that were tested did not have intrinsic antinociceptive activity.•Multiple CRAs were more potent than one CRA in enhancing morphine analgesia.•Combining CRAs + morphine did not increase morphine-induced respiratory depression.

查看译文

关键词

Morphine,Chemokines,Chemokine receptor antagonists,Pain,Analgesia,Respiratory depression

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要