Haemodynamic analysis using multiphase flow dynamics in tubular lesions

•A novel CFD solver for simulating multiphase flows is used for modelling blood flow in tubular lesions using level set for a sharp interface representation.•The impact of hematocrit and degree of stenosis on the haemodynamics of tubular coronary lesions is investigated.•Comparisons with single-phase flow demonstrate the differences in pressure-drop in eccentric lesions when considering the mixture with all the involved fluid forces.•Single-phase simulations over-predict the pressure drop for the same stenosis severity compared to the multiphase simulations.•Changes in hematocrit influence shear stress in coronary arteries.