The monomer derivative of paeoniflorin inhibits macrophage pyroptosis via regulating TLR4/ NLRP3/ GSDMD signaling pathway in adjuvant arthritis rats

•Macrophage pyroptosis was involved in the inflammatory mechanism of AA rats.•TLR4/NLRP3/GSDMD signaling pathway mediated macrophage pyroptosis in AA rats.•MDP can improve the secondary inflammation of AA rats.•MDP inhibited macrophage pyroptosis by regulating TLR4/NLRP3/GSDMD signaling pathway in AA rats.